Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bepridil hydrochloride (CERM 1978) 是一种钙通道阻滞剂,还抑制 Na+/Ca2+ 交换(NCX)、钠通道和心脏肌膜 KATP 通道,具有抗心绞痛的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 251 | 现货 | ||
5 mg | ¥ 417 | 现货 | ||
10 mg | ¥ 583 | 现货 | ||
25 mg | ¥ 987 | 现货 | ||
50 mg | ¥ 1,480 | 现货 | ||
100 mg | ¥ 2,220 | 现货 | ||
200 mg | ¥ 3,330 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 456 | 现货 |
产品描述 | Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels. |
体外活性 | Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2]. |
体内活性 | The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1]. |
别名 | CERM 1978, 盐酸苄普地尔 |
分子量 | 403 |
分子式 | C24H35ClN2O |
CAS No. | 68099-86-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL (322.58 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4814 mL | 12.4069 mL | 24.8139 mL | 62.0347 mL |
5 mM | 0.4963 mL | 2.4814 mL | 4.9628 mL | 12.4069 mL | |
10 mM | 0.2481 mL | 1.2407 mL | 2.4814 mL | 6.2035 mL | |
20 mM | 0.1241 mL | 0.6203 mL | 1.2407 mL | 3.1017 mL | |
50 mM | 0.0496 mL | 0.2481 mL | 0.4963 mL | 1.2407 mL | |
100 mM | 0.0248 mL | 0.1241 mL | 0.2481 mL | 0.6203 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bepridil hydrochloride 68099-86-5 Membrane transporter/Ion channel Metabolism Calcium Channel CERM1978 CERM 1978 inhibit Ca2+ channels Bepridil CERM-1978 Inhibitor Ca channels 盐酸苄普地尔 Bepridil Hydrochloride inhibitor